Abstract：Objective To observe the effect of the combined application of fluoxetine hydrochloride and repetitive transcranial magnetic stimulation on suicidal ideation in adolescents with depression.Methods From April 2022 to February 2024, 40 adolescents with depression were randomly selected from our hospital and divided into a control group (20 cases, treated with fluoxetine hydrochloride) and a study group (20 cases, treated with fluoxetine hydrochloride combined with repetitive transcranial magnetic stimulation) using the lottery method. The treatment efficacy, cognitive function, suicidal ideation, and adverse reactions were compared between the two groups. Results After treatment, the study group showed higher treatment efficacy and cognitive function (number of correct responses, number of completed categories) and lower suicidal ideation than the control group (P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Adolescents with depression who received fluoxetine hydrochloride combined with repetitive transcranial magnetic stimulation achieved better treatment outcomes, improved cognitive function, reduced suicidal ideation, and showed no significant adverse reactions.
Keywords : Fluoxetine hydrochloride; Repetitive transcranial magnetic stimulation; Adolescent depression; Suicidal ideation
参考文献
[1] 黄自珍, 张静娜, 熊艳萍, 等. 盐酸氟西汀结合重复经颅磁刺激治疗青少年抑郁自杀意念患者中的临床疗效研究[J]. 江西医药,2024,59(4):349-353.
[2] 程婷婷, 吴远雄, 夏梦君. 盐酸氟西汀联合重复经颅磁刺激治疗抑郁症患者的疗效及对FGF2、BDNF 水平的影响[J]. 中国医师杂志,2025,27(8):1252-1255.
[3] 殷凤娟, 黄坤鹏, 张艳. 盐酸氟西汀结合重复经颅磁刺激治疗抑郁症伴焦虑疗效观察[J]. 实用中西医结合临床,2021,21(1):102-103.
[4] 李志平, 李建军, 张志明. 艾地苯醌片联合经颅磁刺激治疗缺血性脑卒中后抑郁的临床效果[J]. 临床合理用药,2025,18(2):1-3.
[5] 王梦欣, 祝玲俐. 深部经颅磁刺激联合氟西汀对青少年抑郁症患者HPA 轴及炎症因子的影响[J]. 中国基层医药,2025,32(5):657-662.
[6] 李航, 安敏杰. 运动区低频重复经颅磁刺激联合盐酸氟西汀治疗强迫障碍的效果与安全性[J]. 中外医学研究,2025,23(10):20-24.
[7] 刘思芸. 重复经颅磁刺激对卒中后抑郁患者的疗效及白质纤维束弥散张量成像改变的临床研究[D]. 锦州医科大学,2024.
[8] 裴丽粉, 陈力, 刘欢欢. 盐酸氟西汀联合高频rTMS 对抑郁症患者抑郁程度及血清RBP4、SP 水平的改善作用分析[J]. 航空航天医学杂志,2024,35(12):1461-1463.
[9] 邹晓伟. 低频重复经颅磁刺激对青少年抑郁症伴非自杀性自伤患者情绪调节的影响[D]. 江西: 南昌大学,2023. |
